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KMID : 0388120070160030095
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Journal of Korean Society for the Study of Obesity
2007 Volume.16 No. 3 p.95 ~ p.101
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The Relationship between Serum Adiponectin and Non-Alcoholic Fatty Liver Disease in Obese Children
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Kim Ji-Hee
Choung Ji-Tae
Shin Jung-Yeon
Choi Byung-Min
Lee Kee-Hyoung
Park Sang-Hee
Kim Soo-Young
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Abstract
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Background: In obese adults, non-alcoholic steatohepatitis (NASH) is closely associated with adiponectin and insulin resistance. We investigated the relationship of serum adiponectin with non-alcoholic fatty liver disease in obese children.
Methods: The study population consisted of children from 7 to 15 years old. We measured 8 hour fasting serum glucose, liver enzymes, insulin, adiponectin and lipid profile. We performed ultrasonography to evaluate the fatty liver in 49 obese children.
Results: 1) Mean body mass index was 23.95 kg/m2. 2) Alanine aminotransferase (ALT) was 14.16 IU/L in normal weight, 44.65 IU/L in overweight, 46.71 IU/L in obese children. There were significant differences in total cholesterol, LDL-cholesterol among normal weight, overweight, obese children. 3) Serum adiponectin was 30.63 microgram/mL in normal weight, 24.05 microgram/mL in overweight and 20.84 microgram/mL in obese children. 4) Among the obese children, 17 subjects (34.7%) were presumed to have NASH. Reduced serum adiponectin level was noted among obese children with presumed NASH in contrast to those of obese children with normal liver.
Conclusion: In this study, decreased adiponectin level had closely related with presumed NASH in obese children. Our results suggest that adiponectin plays an important role in the development of NASH in obese children.
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KEYWORD
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Obesity, Children, Adiponectin, Nonalcoholic fatty liver disease (NAFLD)
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